Novel Roles for Chloride Channels, Exchangers, and Regulators in Chronic Inflammatory Airway Diseases

Figure 4

Domain architecture schematic for human SLC26 family proteins discussed here, SLC26A4 (pendrin) and SLC26A9, based on the crystal structure of SLC26Dg (PDB ID 5DA0). Upper inset shows general schematic while the lower insets show details of the C-terminal cytoplasmic region for each protein. Labels denote the following domains: STAS: sulfate transporter and antisigma factor antagonist domain; PDZ: PSD95-Dlg1-Zo-1 domain. Locations of SLC26A9 interaction with CFTR R domains and WNK kinases are denoted. The location of residues of a crystallographically determined ligand binding site is highlighted with stars.