Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells

Figure 1

Venn diagrams on IL27- and calprotectin-stimulated HUVECs including significant regulated genes with value : red: upregulated, green: downregulated, and black: up- and downregulation different in compared concentrations. (a) Venn diagram: HUVECs stimulated with IL27 (10, 30, and 100 ng/mL). (b) Venn diagram: HUVECs stimulated with calprotectin (1, 5, and 10 μg/mL). ACE, angiotensin-converting enzyme; BCL2, B-cell lymphoma 2; BCL2L1, BCL2-like 1; C3, complement component 3; CD, cluster of differentiation; CSF, colony stimulating factor; CCL2/MCP-1, monocyte chemotactic protein-1; CCL5/RANTES, regulated on activation, normal T cell expressed and secreted; CXCL10, interferon gamma-induced protein 10; CXCL11, interferon-inducible T cell alpha chemoattractant; CYP7A1, cholesterol 7 alpha-hydroxylase; FAS, Fas cell surface death receptor; ICAM1, intercellular adhesion molecule 1; IKBKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; IL, interleukin; LTA, lymphotoxin-α; NFKB2, nuclear factor-kappa-B p100 subunit; NOS2A, inducible nitric oxide synthase; PGK1, phosphoglycerate kinase 1; PTGS2, prostaglandin G/H synthase and cyclooxygenase; SELE, selectin E; SELP, selectin P; SMAD3, mothers against decapentaplegic homolog 3; STAT, signal transducers and activators of transcription.

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