Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury

Figure 3

Autoimmune hepatitis. Histological examination showed centrilobular hepatic necrosis with punched out lesions, acidophilic body formation, enlargement of Kupffer cells, and sinusoidal lymphocyte infiltration. Moderate lymphocyte infiltration was observed in the portal areas. Eosinophilic infiltration was also observed. The histological findings were consistent with a diagnosis of acute severe hepatitis with confluent necrosis (needle biopsy, H&E). C: central vein; P: portal vein.