Oxidative-Nitrosative Stress and Myocardial Dysfunctions in Sepsis: Evidence from the Literature and Postmortem Observations

Figure 3

Nitrotyrosine (NT) expression in the cardiac tissue of patient died following sepsis. Bright field (a) and contrast phase (b) microscopy image of cardiac sample of a septic patient, showing a strong immunopositivity to anti-nitrotyrosine antibody (Abcam, Cambridge, UK). Personal observation of a 60-year-old man diagnosed with acute suppurative cholangitis and treated with antibiotic therapy and endoscopic drainage. Jaundice slightly improved; however, on the third day after admission, an echocardiography showed biventricular wall dysfunction. The patient died on third day despite massive fluid and vasopressor support.

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