IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

<div>IL-6 expression and STAT3 activation in human colorectal carcinoma: (a) human colorectal carcinoma and nontumor samples were collected at surgery and paraffin-embedded sections were used for the immunohistochemistry detection of IL-6, p-STAT3, and STAT3. Representative images (200x magnification) were shown. (b) Western blot showing the expression of p-STAT3, STAT3, IL-6, and <i>β</i>-actin (internal control) in normal colorectal tissue, high grade colorectal carcinoma, and low grade colorectal carcinoma.</div>

Mediators of Inflammation

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Figure 1

Figure 1: IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin 