IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

<div>Western blot analysis of STAT3 and downstream molecules: LoVo cells were treated with 20 <i>μ</i>g/mL CBP, 500 <i>μ</i>g/mL IL-6 neutralizing antibody (Ab), or both combined or PBS control for 24 h. Total proteins were then isolated for the western blot detection of p-STAT3, total STAT3, cyclin D1, cleaved caspase-3, and GAPDH.</div>

Mediators of Inflammation

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Figure 5

Figure 5: IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin 