MALAT1 Mediates α-Synuclein Expression through miR-23b-3p to Induce Autophagic Impairment and the Inflammatory Response in Microglia to Promote Apoptosis in Dopaminergic Neuronal Cells

Figure 5

α-Synuclein affects microglial activation by mediating autophagy. (a) The level of MIP-1α was detected by ELISA, vs. control and ^#### vs. α-synuclein. (b) The level of TNF-α was detected by ELISA, vs. control and ^#### vs. α-synuclein. (c) The level of IL-1β was detected by ELISA, vs. control and ^#### vs. α-synuclein. (d) The level of IL-6 was detected by ELISA, vs. control and ^#### vs. α-synuclein. (e) The level of INF-γ was detected by ELISA, vs. control and ^#### vs. α-synuclein. (f) NF-κB p65 nuclear translocation assay, scale  px. (g) The expressions of LC3 II/I, Beclin 1, and p62 were detected by western blot, , , and vs. control, ^#, ^## vs. α-synuclein.

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