The Clinical Application and Progress of Mirogabalin on Neuropathic Pain as a Novel Selective Gabapentinoids

Table 2

Coadministration effect and drug-drug interaction with mirogabalin.

No.	Author	Year	Race	Mirogabalin	Concomitant medicine		PK parameter of mirogabalin	Safety assessment	Conclusion
				Dose	Drug	Dose
1	James Dow et al.	2018	Unknown	15 mg	Metformin	850 mg	PK parameters were similar when administered alone or in combination	Dyspepsia, encephalalgia, increased hepatic enzymes (AST and ALT were 2.7 and , respectively).	Well tolerated with no evidence of a drug-drug interaction.
2	Mendel Jansen et al.	2018	Unknown	20 mg	Lorazepam	2 mg	PK parameters were similar when administered alone or in combination	Increased effects in body sway and DSST assays; increased occurrence of somnolence.	Potentially increased central nervous system-related AEs when lorazepam or ethanol was coadministered with mirogabalin.
					Zolpidem	10 mg	decreased by 11%, (90% CI), 0.89 (0.82, 0.96)	Increased occurrence of somnolence.
					Tramadol	100 mg	decreased by 28%, (90% CI), 0.72 (0.67, 0.76)	Increased incidence of nausea.
					Ethanol	240 mL men/200 mL women	increased by 20%, (90% CI), 1.20 (1.12, 1.28)	Increased the PD effects in body sway and DSST assays; increased incidence of encephalalgia.
3	Masaya Tachibana et al.	2018	White, Black, African American	15 mg	Probenecid	500 mg Q6H	AUC0-last and increased by 76% and 29%	No clinically significant changes in vital signs or ECGs.	No necessary to dose adjustment with administration of probenecid and cimetidine, since the effect was not significant (>2-fold).
					Cimetidine	400 mg Q6H	AUC0-last and increased by 44% and 17%

ULN: upper limit of normal; Q6H: once every 6 h; DSST: digit symbol substitution test; AST: aspartate aminotransferase; ALT: alanine transaminase; ECGs: 12-lead electrocardiograms.