The Causal Relationship between Plasma Myeloperoxidase Levels and Respiratory Tract Infections: A Bidirectional Mendelian Randomization Study

Table 2

Pleiotropy and heterogeneity test of the bidirectional Mendelian randomization study.

Exposure	Outcome	Pleiotropy test				Heterogeneity test
		MR-Egger			PRESSO	MR-Egger			IVW
		Intercept	SE	P-value	P-value	Q	Q_df	Q_P val	Q	Q_df	Q_P val
	URTI	−0.005	0.012	0.674	0.972	14.526	26	0.965	14.707	27	0.973
	LRTI (ICU)	−0.001	0.027	0.957	0.908	18.768	27	0.878	18.771	28	0.905
MPO#	URTI	−0.007	0.024	0.790	0.923	4.462	9	0.878	4.537	10	0.920
MPO#	LRTI (ICU)	−0.009	0.052	0.865	0.901	5.003	9	0.834	5.034	10	0.889
URTI		−0.008	0.009	0.406	0.972	3.719	11	0.977	4.466	12	0.973
LRTI (ICU)		0.007	0.021	0.749	0.945	1.570	5	0.905	1.684	6	0.946
URTI	MPO#	0.008	0.026	0.773	0.428	10.069	9	0.345	10.168	10	0.426
LRTI (ICU)	MPO#	−0.013	0.047	0.790	0.948	1.574	5	0.904	1.653	6	0.949

Horizontal pleiotropy analyses were conducted by MR-Egger regression and MR-PRESSO methods, and the results showed that there is no evidence of horizontal pleiotropy in IVs of infectious diseases (all ). Heterogeneity tests were conducted by MR-Egger regression and IVW with the fixed model, and the results showed that there is no evidence of heterogeneity in IVs of infectious diseases (all ). PRESSO, MR-Pleiotropy RESidual Sum and Outlier; IVW, inverse variance weighted method with the fixed effect model. , MPO-related SNPs from the Folkersen et al. [20] study; MPO#, MPO-related SNPs from INTERVAL study [21].