Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis

Figure 1

Tanshinone IIA pretreatment reduces I/R-induced brain injury. (a) Chemical structure of Tanshinone IIA; (b) TTC staining of the brain infarct area; (c) neurological scores; (d) changes in brain infarct volume; (e) wet and dry brain water content; (f) Nissl analysis of surviving neurons in the rat cortex, scale bar = 100 μm; (g) quantification of surviving neurons in the rat cortex; (h) MTT analysis of cell viability; (i) LDH assay of cell damage. , compared with the Sham group or NC group; ^#, ^##, ^### compared with the MCAO group or OGD group.

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