Research Article
Tanshinone IIA Alleviates Traumatic Brain Injury by Reducing Ischemia‒Reperfusion via the miR-124-5p/FoxO1 Axis
Figure 6
Inhibiting miR-124-5p or increasing FoxO1 abolished the inhibitory effect of Tanshinone IIA on I/R-induced brain injury. (a) TUNEL analysis of apoptosis in rat cortical cells, scale bar = 100 μm; (b–d) ELISA analysis of IL-1β, IL-6, and TNF-α levels; (e) The expressions of apoptosis-related proteins were analyzed by western blot; (f) RT-qPCR was used to analyze the mRNA expression of apoptosis related proteins. , compared with the Sham group; #, ## compared with the MCAO group; &, && compared with the Tan IIA group.
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