Continuous liver inflammation causes fibrotic changes and leads to the development of liver cirrhosis and liver cancer. Chronic liver inflammation is induced by a wide range of diseases, such as hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, parasitic infections, alcoholic liver disease, nonalcoholic steatohepatitis (NASH), and autoimmune liver diseases.

Recent biological and medical advances have clarified the mechanisms of chronic liver inflammation and succeeded in providing new therapies for various liver diseases. The aim of this issue is to summarize the current status of the basic and clinical findings in chronic liver inflammation and its complications. Such information will help develop better management programs for patients and can improve their prognosis.

We invite authors to contribute original research articles as well as review articles that will provide the recent findings about chronic liver inflammation. We are particularly interested in the molecular mechanisms of chronic liver inflammation (e.g., toll-like receptor signaling) and also in the treatment of the chronic liver inflammation and its complications.

Potential topics include, but are not limited to:

• Molecular mechanisms and immune responses to infection with HBV/HCV
• Molecular mechanisms and immune responses to infection with parasitic infections
• Molecular mechanisms and immune responses to NASH
• Molecular mechanisms and immune responses to alcoholic liver disease
• Molecular mechanisms and immune responses to autoimmune liver diseases
• Molecular mechanisms underlying the development and progression of liver fibrosis
• Recent advances in the antiviral treatment of HBV/HCV infection
• Recent advances in the anti-inflammatory treatment of nonviral liver diseases (including alcoholic liver disease and NASH)
• Recent advances in the treatment of liver cirrhosis