Under physiological conditions, external and internal inflammatory stimuli trigger inflammation, further initiating the healing process and helping restore homeostasis. However, uncontrolled inflammatory responses disrupt tissue homeostasis and contribute to inflammation-associated diseases, including arthritis, diabetes, obesity, cancer, cardiovascular diseases, and other degenerative disorders, as well as acute and chronic health issues. Inflammation is a multi-component system that comprises a network of various cells and mediators, in which cellular crosstalk is fundamental. Immune cells, such as neutrophils, macrophages, or NK cells, are the major purveyors of inflammatory action and can supply pro- or anti-inflammation factors, including cytokines, metabolites, and other chemicals, to modulate inflammatory activities.

The communication between different immune cells and their interplay with the tissue parenchyma, such as epithelial cells, endothelial cells, and fibroblasts, play a vital role in inflammation processes. Intracellular crosstalk is another kind of cellular crosstalk process through which a message is transmitted within an individual cell. Cellular activities are regulated by the integrated processes mediated by the tight mutual interplays, among a variety of signalling molecules, which can transmit between different intracellular organelles and compartments. Cellular crosstalk makes the cells or molecules within cells closely interact with each other and form a regulatory network involved in inflammation-associated diseases, contributing to the occurrence, development, and alleviation of the course of the disease.

The aim of this Special Issue is to provide valuable insights into the pathophysiological processes of inflammation-associated diseases and help develop efficient strategies to promote disease resolution by systematically charting these essential processes as diseases develop. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

• Crosstalk between different types of immune cells in the setting of inflammation-associated diseases
• The roles of inflammatory factors in cellular crosstalk in the context of inflammation-associated diseases
• The effect of metabolites and chemicals on inflammation-associated diseases
• Immune-epithelial crosstalk in the progression of inflammation-associated diseases
• Interactions between fibroblasts and immune cells in the pathogenesis of inflammation-associated diseases
• Endothelial-immune interactions in inflammation-associated diseases
• Cooperation between innate and adaptive immune cells in inflammation-associated diseases
• Regulatory networks in the tissue microenvironment in inflammation-associated diseases
• Mutual interplay among signalling molecules within cells correlated with inflammation-associated diseases
• Communication between different intracellular organelles and compartments within cells involved in inflammation-associated diseases
• Translational potentials of emerging mechanisms of cellular crosstalk in inflammation-associated diseases