Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53

<table>BIBF1120+paclitaxel modifies G2/M checkpoint controllers to induce transition into M phase. The effect of 1 <i>μ</i>M BIBF1120, 14 nM paclitaxel, and combination treatment (24 h) on the posttranslational modification of cell cycle regulators was examined by Western blotting. *denotes slower-migrating CDC25C, indicative of activating phosphorylation.</table>

Obstetrics and Gynecology International

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Figure 5

Figure 5: Strategies for Molecularly Enhanced Chemotherapy to Achieve Synthetic Lethality in Endometrial Tumors with Mutant p53 