A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer

Figure 7

Representation of the β-oxidation of palmitic acid in the mitochondria (according to Carracedo et al. [48], with permission of the Nature Publishimg Group). Acyl-CoAs enter the fatty acid oxidation pathway in which they are dehydrogenated, hydrated, and decarboxylated cyclically. This results in the progressive shortening of the fatty acid. The produced NADH and FADH₂ can be used for ATP production in the electron transport chain, and acetyl-CoA can enter the Krebs cycle. S-CoA: free coenzyme A.