A “Weird” Mitochondrial Fatty Acid Oxidation as a Metabolic “Secret” of Cancer

Figure 9

Schematic representation of the “reverse electron transport” (RET) in mitochondria (adapted according to Chance and Hollunger [112] and Warshaw et al. [113]). Mitochondria could synthesize NADH from NAD⁺ when there is enough ATP in the system plus some substrate that could inject electrons into the electron-transport chain, such as succinate, ascorbate, quinones, tetramethyl-phenylenediamine (TMPD), pyocyanin, and other artificial electron donors.