Polysaccharides from <i>Polygonatum cyrtonema</i> Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis

<div>PSP exerts antidepressant effects by regulating the oxidative stress-calpain-1-neuroinflammation signaling axis. Calpain-1 may bridge inflammation and oxidative stress, two relatively independent mechanisms of depression, while PSP plays an antidepressant effect by regulating the signaling axis of oxidative stress-calpain-1-neuroinflammation.</div>

Oxidative Medicine and Cellular Longevity

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Figure 10

Figure 10: Polysaccharides from <i>Polygonatum cyrtonema</i> Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis 

Figure 10 | Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis 