Polysaccharides from <i>Polygonatum cyrtonema</i> Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis

<div>PSP inhibited LPS-induced expression of calpain-1 and degradation of its substrates. (a–c) show the representative blots of calpain-1, calpain-2, calpastatin, and quantification data for calpain-1/<i>β</i>-actin, calpain-2/<i>β</i>-actin, and calpastatin/<i>β</i>-actin in experiment 1. (d–f) show representative blots of calpain-1, calpain-2, calpastatin, and quantification data for calpain-1/<i>β</i>-actin, calpain-2/<i>β</i>-actin, and calpastatin/<i>β</i>-actin. (g) shows representative blots of SCOP and PTEN. (h) shows the quantification data for SCOP/<i>β</i>-actin and PTEN/<i>β</i>-actin. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Polysaccharides from <i>Polygonatum cyrtonema</i> Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis 

Figure 3 | Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis 