Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy

<div>Hair and body weight characteristics of C57BL/6 mice that received ND or HFD. (a) Mice (13-month-old C57BL/6) were fed HFD or ND for 6 months. (b) The hair of mice in the HFD group was slightly sparse, dull, and without luster compared with the ND group. 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-3Z"></path></g><g transform="matrix(.013,0,0,-0.013,34.265,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,40.505,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.469,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,49.709,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> Abbreviations: HFD: high-fat diet; ND: normal diet; TEM: transmission electron microscopy; WB: western blotting; IF: immunofluorescence.</div>

Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy 