Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy

Figure 2

HFD aggravates spatial learning and memory abilities. (a) Schematic diagram and behavioral tests in aged C57BL/6 mice. C57BL/6 mice (13-month-old) were divided into two groups: the ND group was fed a normal diet, and the HFD group was fed a fat-rich diet for 6 months. HFD led to significant changes in the average escape latency (time to find the platform) (b), number of entries to the platform (c), time on the platform (d), and distance traveled on the platform (e), as compared to ND. There was no difference in the swimming speed between ND and HFD mice (f). Representative illustrations show the trajectories of mice in the final probe test in each experimental group (g). , two-sample -test. Data are shown as the , , . Abbreviations: HFD: high-fat diet; ND: normal diet.

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