Research Article
Dietary High-Fat Promotes Cognitive Impairment by Suppressing Mitophagy
Figure 6
Long-term dietary fat induces tau protein hyperphosphorylation. (a) Schematic diagram of a synapse. (b, c) High-fat treatment for 6 months led to an increase in p-Tau (Thr231, Ser396, Ser205, and Ser404) in mice (, two-sample -test). (d, e) The cells treated with PA (200 μM) showed upregulated levels of p-Tau (Thr231, Ser396, and Ser404) compared with the CON group and high fat cells treated with Kaem (, one-way ANOVA). The relative level of proteins is normalized to GAPDH. All data are expressed as ; , . Abbreviations: ND: normal diet; HFD: high-fat diet; CON: control; PA: palmitic acid; TNF: neurofibrillary tangles.
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