Clinical Features and Body Composition in Men with Hormone-Sensitive Metastatic Prostate Cancer: A Pilot Study Examining Differences by Race
Table 2
Body composition characteristics in Black versus non-Black men with treatment naïve hormone-sensitive metastatic prostate cancera.
Overall N = 55
Non-Black n = 40
Black n = 15
value
Body weight, kg (median, IQR)
88.0 (74.8–99.2)
85.6 (75.1–93.9)
92.1 (64.5–103.6)
0.3119
Body mass index category, kg/m2
0.1923
18.5–24.9 kg/m2, n (%)
12 (22)
8 (20)
4 (27)
25.0–29.9 kg/m2, n (%)
25 (46)
21 (54)
4 (27)
≥30.0 kg/m2, n (%)
17 (32)
10 (26)
17 (46)
Sarcopenia,bn (%)
27 (49)
22 (55)
5 (33)
0.1523
Sarcopenic obesity,cn (%)
8 (15)
6 (15)
2 (13)
1.0000
Skeletal muscle index, cm2/m2 (median, IQR)
49.8 (40.2–56.2)
49.7 (39.8–54.3)
56.2 (47.3–62.7)
0.0682
Skeletal muscle HU (median, IQR)
33.8 (26.3–41.8)
32.5 (26.9–42.6)
35.5 (23.1–43.9)
0.6707
Myosteatosisd (n, %)
27 (49)
21 (53)
6 (40)
0.4089
Visceral adipose tissue (cm2) (median, IQR)
187.5 (106.5–302.2)
199.8 (147.4–296.7)
73.5 (53.5–319.3)
0.0441
Visceral adipose tissue index (cm2/m2) (median, IQR)
61.6 (33.6–98.9)
73.7 (46.9–102.6)
25.1 (17.5–93.1)
0.0441
Visceral adipose tissue HU (median, IQR)
−86.9 [(−93.3)–(−81.4)]
−88.3 [(−93.3)–(−83.6)]
−81.5 [(−96.0)–(−73.6)]
0.2450
Subcutaneous adipose tissue (cm2) (median, IQR)
162.0 (99.2–216.3)
146.4 (97.9–206.7)
188.6 (103.7–243.6)
0.3899
Subcutaneous adipose tissue index (cm2/m2) (median, IQR)
51.9 (33.3–69.4)
51.6 (33.2–65.9)
56.3 (35.1–80.5)
0.0440
Subcutaneous adipose tissue HU (median, IQR)
−92.1 [(−99.6)–(−84.0)]
−94.9 [(−99.5)–(−85.1)]
−89.5 [(−100.9)–(−65.5)]
0.2730
Intramuscular adipose tissue (cm2) (median, IQR)
18.1 (13.1–23.8)
18.3 (13.3–23.0)
17.3 (10.8–25.5)
0.9022
Intramuscular adipose tissue HU (median, IQR)
−36.7 [(−46.3)–(29.1)]
−39.3 [(−50.2)–(28.6)]
−34.7 [(−40.0)–(30.6)]
0.2301
aHU = Hounsfield units and IQR = interquartile range. bSarcopenia defined as skeletal muscle index <43 for BMI <25.0 kg/m2 and skeletal muscle index <53 for BMI ≥25.0 kg/m2 per the cut-points of Martin et al. [29]. cSarcopenic obesity defined as a combination of BMI ≥30 kg/m2 and L3 SMI <53 cm2/m2. dMyosteatosis defined as <41 SMHU for BMI <24.9 kg/m2 and <33 SMHU for BMI ≥25.0 kg/m2 per the cut-points of Martin et al. [29].
