Review Article
Importance of the Brain Angiotensin System in Parkinson’s Disease
Table 2
Ligand activation of the AT1, AT2, and AT4 receptor subtypes influence the following functions.
| AT1 receptor subtype | | Vasoconstriction | | Aldosterone release | | Vasopressin release | | Cardiac hypertrophy | | Fibrosis | | Proliferation | | Inflammation | | Platelet aggregation | | Oxidative stress | | Endothelial disruption | |
| AT2 receptor subtype | | Vasodilation | | Antifibrotic | | Antiproliferative | | Antihypertrophic | | Antithrombotic | |
| AT4 receptor subtype | | Dendritic arborization | | Changes in blood flow | | Memory facilitation | | Protection against seizures | | Facilitates wound healing | |
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