Research Article
Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study
Table 3
Incident rate and hazard ratio for dementia with PD.
| Group | Without PD | With PD | Crude HR (95% CI) | | Adjusted HRb (95% CI) | | Incident ratea | Incident ratea |
| Overall | 8.3 | 24.2 | 2.91 (2.39–3.53) | <0.001 | 3.05 (2.51–3.70) | <0.001 | Female | 7.9 | 22.5 | 2.87 (2.16–3.82) | <0.001 | 2.92 (2.19–3.89) | <0.001 | Male | 8.7 | 25.8 | 2.94 (2.26–3.83) | <0.001 | 3.20 (2.45–4.17) | <0.001 | Age, years | | | | | | | <50 | 0.2 | 2.5 | 10.14 (1.97–52.26) | 0.006 | 12.10 (2.15–68.04) | 0.005 | 50–64 | 1.3 | 13.1 | 9.84 (4.51–21.49) | <0.001 | 9.59 (4.38–20.98) | <0.001 | ≧65 | 15.4 | 42.3 | 2.78 (2.26–3.42) | <0.001 | 2.74 (2.22–3.36) | <0.001 | Depression | | | | | | | Noc | 7.9 | 29.2 | 3.71 (3.00–4.58) | <0.001 | 3.30 (2.67–4.07) | <0.001 | Yesc | 13.7 | 13.2 | 0.97 (0.58–1.61) | 0.905 | 1.77 (1.06–2.96) | 0.030 |
|
|
Note. PD = Parkinson’s disease, HR = hazard ratio, CI = confidence interval, n = case number, % = percentage, and = value. aPer 1000 person-years. bAdjusted HR: adjusted for age, gender, hypertension, diabetes mellitus, hyperlipidemia, and ischemic heart disease. c“No” = without depression; “yes” = with depression. |