Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson’s Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics

Table 1

Demographic and clinical characteristics of all subjects.

	NC (n = 21)	RBD (n = 24)	PD (n = 45)	-value
Gender (M : F)	17 : 4	21 : 3	24 : 21	0.003
Age (years)	65.0 ± 9.3	71.6 ± 5.5	60.3 ± 7.4	0.000
UPDRS_I	2.6 ± 2.0	11.7 ± 5.0	9.1 ± 5.0	0.000
UPDRS-II	0.7 ± 1.8	4.6 ± 5.1	7.2 ± 4.9	0.000
UPDRS_III	1.0 ± 1.5	4.4 ± 5.7	19.0 ± 7.9	0.000
UPDRS_total	4.3 ± 4.1	20.6 ± 12.4	35.3 ± 13.7	0.000
RBDSQ	3.2 ± 1.7	10.3 ± 2.2	5.0 ± 3.0	0.000
MoCA	28.0 ± 1.2	26.8 ± 2.4	27.0 ± 2.8	0.275

Abbreviations: NC : normal control; RBD : rapid eye movement sleep behavior disorder; PD : Parkinson’s disease; UPDRS : new version of the world movement disorder society Parkinson’s disease comprehensive rating scale (part I: mood/cognition, part II : activities of daily living, part III : motor examination, total : sum of parts I–III); RBDSQ : RBD symptom questionnaire; MoCA : montreal cognitive assessment.