Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson’s Disease

Rosqvist, Kristina; Odin, Per

doi:https://doi.org/10.1155/2023/6667339

Parkinson’s Disease

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Abstract Introduction Methods Results Discussion Conclusions Data Availability Disclosure Conflicts of Interest Acknowledgments References Copyright Related Articles

Research Article | Open Access

Volume 2023 | Article ID 6667339 | https://doi.org/10.1155/2023/6667339

Compliance with National and International Guidelines in the Treatment of Nonmotor Symptoms in Late-Stage Parkinson’s Disease

Kristina Rosqvist^1,2and Per Odin^1,2,3

Academic Editor: Seyed-Mohammad Fereshtehnejad

Received05 Jun 2023

Revised01 Aug 2023

Accepted21 Sept 2023

Published10 Oct 2023

Abstract

Background. National as well as international Parkinson’s disease (PD) treatment guidelines are available to guide clinicians. Previous research has shown that nonmotor symptoms (NMS) are pronounced in late-stage PD and has suggested that current treatment is insufficient and could be improved. Objectives. The aim of this study was to investigate to which degree the national and international treatment guidelines are followed in the treatment of NMS in late-stage PD. Methods. This Swedish cohort was part of the Care of Late-Stage Parkinsonism (CLaSP) study. Late-stage PD was defined as Hoehn and Yahr stages IV-V in “on” and/or ≤50% on the Schwab and England Activities of Daily Living (ADL) scale. NMS were assessed with the NMS scale (NMSS), cognition with the Mini-Mental State Examination (MMSE), and depressive symptoms with the Geriatric Depression Scale (GDS-30). Symptomatic individuals were defined as ≥ 6 on an item of the NMSS; for dementia, a cutoff of ≤18 on the MMSE; for depression, a cutoff of ≥10 on the GDS. Results. All 107 participants exhibited NMS to various degrees and severities; the median NMSS score was 91. Among symptomatic individuals, for depressive symptoms, 37/63 (59%) were treated with antidepressants; for hallucinations and delusions, 9/18 (50%) and 5/13 (38%) were treated with antipsychotics; and for dementia, 9/27 (33%) were treated with rivastigmine and 1 (4%) was treated with donepezil. For orthostatic hypotension, 11/19 (58%) with lightheadedness and 7/8 (88%) with fainting were treated with antihypotensives; for sialorrhea, 2/42 (5%) were treated with botulinum toxin; and for constipation, 19/35 (54%) were treated with laxatives. For insomnia, 4/16 (25%) were treated with hypnotics, and for daytime sleepiness, 1/29 (3%) was treated with psychostimulants. Conclusions. The present analyses suggest a need for clinicians to further screen for and treat NMS. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance quality of life in late-stage PD.

1. Introduction

National as well as international guidelines for the treatment of Parkinson’s disease (PD) are available to guide clinicians to improve and optimize equal treatment and care for patients with PD [1–3].

In late-stage PD, i.e., Hoehn and Yahr (HY) stages IV-V [4], motor and nonmotor symptoms (NMS) are pronounced [5–8] and quality of life (QoL) is often reduced [9]. Previous research has suggested that current treatment in late-stage PD remains insufficient [6, 10] and could be improved.

Several studies have indicated that NMS may have a higher impact on QoL than motor symptoms [11–16]. It is therefore of high importance that NMS are screened for and adequately treated, not least in the late stage of the disease.

NMS include neuropsychiatric symptoms such as depressive symptoms, anxiety, apathy, and psychosis [17]; autonomic dysfunction such as orthostatic hypotension (OH), constipation, and difficulty swallowing; sleeping disorders, pain and fatigue [16, 18]. We have previously shown that a large range of NMS and particularly neuropsychiatric symptoms are common and pronounced in late-stage PD [8, 19]. Assessed by the NMS scale (NMSS) [20], the highest scores are found within the domain mood/apathy [8]. Multinational analyses have further confirmed that the most clinically relevant symptoms are apathy, depression, and anxiety [19]. Fatigue is another common and pronounced symptom among late-stage PD patients [6]. Multivariable linear regression analyses of multicenter data from a large cohort of late-stage patients across Europe showed that lower NMSS scores in the domains of mood/apathy, attention/memory, gastrointestinal, and sleep/fatigue were associated with better health-related QoL [9]. NMS affect a large proportion of people in late-stage PD [6, 15], with various symptoms occurring in >80% of the individuals [8]. The frequency of NMS increases with disease severity [11].

The International Parkinson and Movement Disorder Society (MDS) first published treatment recommendations for PD in 2002, which were updated in 2011 and 2016 [3]. The evidence base for the treatment of a range of NMS has increased substantially in recent years. Based on an extensive review of the literature, an update on the treatment of NMS was published in 2019 [3]. In many countries, there are also national PD treatment guidelines.

Against a background of the national and international PD treatment guidelines, the aim of this study was to investigate to which degree the recommendations are followed in the treatment of NMS in late-stage PD.

2. Methods

2.1. Participants and Recruitment

Participants were recruited in the southern region of Sweden through neurology departments and the municipality-based health care system. This cohort constitutes the Swedish part of the European multicenter study Care of Late-Stage Parkinsonism (CLaSP) [6, 21]. Late-stage PD was defined according to the inclusion criteria: HY stages IV-V (score range I–V, higher = worse) [4] in the medication “on” state and/or having a substantial need of help with activities of daily living (ADL), ≤50% on the Schwab and England ADL scale (score range 0–100, higher = better) [22]. Furthermore, participants had to have been diagnosed with PD since at least 7 years. Exclusion criteria were cognitive symptoms that started before the PD diagnosis as well as symptomatic parkinsonism, such as drug-induced parkinsonism or normal pressure hydrocephalus.

2.2. Procedure and Clinical Evaluation

An extensive data collection was carried out through home visits. A complete medication list was acquired from each participant. Nonmotor symptomatology was assessed with the NMSS (score range 0–360, higher = worse) [20]. Motor function was assessed with the Unified PD Rating Scale, UPDRS part III (score range 0–108, higher = worse) [23]. Cognition was assessed with the Mini-Mental State Examination (MMSE, score range 0–30, higher = better) [24]. Depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30; score range 0–30, higher = worse) [25].

In the national as well as international PD treatment guidelines, recommendations for the pharmacological treatment of NMS have been given priority rankings. Priority according to the Swedish National Guidelines (i.e., the Swedish National Board of Health and Welfare’s guidelines and the Swedish Movement Disorder Society’s guidelines on diagnosis and treatment of PD) are categorized in the following way: priority 1–4 = recommended/should be used; priority 5–7 = can be used; priority 8–10 = can be used as an exception; research and education = should be used only in the frame of clinical studies; and non-do = should not be used [1, 2]. International treatment recommendations by the MDS are rated as clinically useful; possibly useful; investigational; and not useful [3].

Frequency and severity of the various NMS have in the present study been categorized in the following way: symptom present = individuals with a score of ≥1 on an item of the NMSS, scored 0–12 (higher = worse) and symptomatic individuals = individuals with a score of ≥6 on an item of the NMSS. For depressive symptoms, the GDS-30 cutoff in screening for depression (≥10 points) was used, where symptom present = 1–9 points and symptomatic individuals = ≥ 10 points. For cognitive symptoms, MMSE cutoffs were used: symptom present = below the cutoff for cognitive impairment of ≤23 points and symptomatic individuals = below the cutoff for possible dementia of ≤18 points on the MMSE.

Permission to use the questionnaires/assessment instruments used in this study has been obtained.

2.3. Ethical Considerations

The study was approved by the Swedish Ethical Review Authority, the Regional Ethical Review Board in Lund, Sweden (JPND HC-559-002). Written informed consent was obtained by the participants.

2.4. Statistical Analyses

Descriptive and clinical data are presented by median and first and third quartiles (q1–q3) and frequencies and percentages, as appropriate. All analyses were performed using IBM SPSS version 26.0 (IBM Corporation, Armonk, NY, USA).

3. Results

3.1. Demographic and Clinical Data

The study consisted of 107 patients in late-stage PD. Their median age was 78 years and their median disease duration was 15 years. The majority of the participants (79; 74%) were in HY stage IV, while 28 (26%) were in stage V. Independence in ADL was median 40% according to the Schwab & England Scale (Table 1). The NMS burden was median 91 points on the NMSS. All individuals exhibited the presence of NMS to various degrees and severities (Table 2).

Among symptomatic individuals (defined as ≥6 on item of the NMSS): for depressive symptoms, 37 of 63 (59%), who were above the ≥10 cutoff of the GDS for depression, were treated with antidepressants, 5 of 63 (8%) with serotonin-norepinephrine reuptake inhibitors (SNRIs)^Prio3 (venlafaxine), 0 with tricyclic antidepressants (TCAs), 16 of 63 (25%) with noradrenergic and specific serotonergic antidepressants (NaSSAs)^{No prio} (mirtazapine), and 16 of 63 (25%) with selective serotonin reuptake inhibitors (SSRIs)^Prio8. For hallucinations, 9 of 18 (50%) symptomatic individuals were treated with antipsychotics, 2 of 18 (11%) with clozapine^Prio3, and 7 of 18 (39%) with quetiapine^Prio7; for delusions, 5 of 13 (38%) were treated with antipsychotics, 3 of 13 (23%) with clozapine^Prio3, and 2 of 13 (15%) with quetiapine^Prio7. For dementia, among those who scored ≤18 on the MMSE, 9 of 27 (33%) were treated with acetylcholinesterase inhibitor rivastigmine^Prio4, 1 of 27 (4%) was treated with acetylcholinesterase inhibitor donepezil^Prio4, and 10 of 27 (37%) were treated with memantine^Prio9. For OH, 11 of 19 (58%) with lightheadedness and 7 of 8 (88%) with fainting were treated with antihypotensives. For sialorrhea, 2 of 42 (5%) were treated with botulinum toxin^Prio4; for constipation, 19 of 35 (54%) were treated with laxatives. For insomnia, 4 of 16 (25%) were treated with hypnotics; for daytime sleepiness, 1 of 29 (3%) was treated with psychostimulants (Table 3).

A more detailed description of pharmacological interventions recommended by the MDS in relation to their prescription in the current sample is given in Table 4. Among symptomatic individuals, for depression or depressive symptoms, 20 of 63 (32%) were treated with the dopamine-agonist pramipexole, rated as clinically useful according to MDS. No individuals were treated with TCA nortriptyline or desipramine; one was treated with amitriptyline (all alternatives were rated as possibly useful). As for SSRI/SNRI, 11 of 63 (17%) symptomatic individuals were treated with citalopram, 4 of 63 (6%) were treated with sertraline, none were treated with paroxetine, 1 of 63 (2%) was treated with fluoxetine (all alternatives rated as possibly useful), and 5 of 63 (8%) were treated with venlafaxine (rated as clinically useful). For lightheadedness, 3 of 19 (16%) symptomatic individuals were treated with fludrocortisone, 7 of 19 (37%) with midodrine, and none were treated with droxidopa (all alternatives rated as possibly useful). For fainting, no symptomatic individuals were treated with fludrocortisone or droxidopa, while 5 of 8 (63%) were treated with midodrine. For insomnia, 1 of 16 (6%) symptomatic individuals was treated with rotigotine (possibly useful), 3 (19%) with eszopiclone (possibly useful), and 1 (6%) with melatonin (possibly useful). For pain, among symptomatic individuals, 2 of 33 (6%) were treated with oxycodone-naloxone prolonged release (possibly useful), and for fatigue, 4 of 40 (10%) were treated with rasagiline (possibly useful).

4. Discussion

Treating clinicians have the support of national as well as international PD guidelines in the treatment of nonmotor symptomatology. The present results confirm that NMS are common and pronounced in late-stage PD and these analyses suggest that there may be a need for clinicians to further screen for and treat NMS in late-stage PD.

In the CLaSP project, which investigated the effect of specialist recommendations on therapy, it was concluded that clinicians who care for late-stage PD patients should be aware of the frequent occurrence of neuropsychiatric symptoms in this group [19]. This is in line with previous research, showing a high prevalence of neuropsychiatric symptoms in the advanced stages of the disease [17], including an increased risk of depression and psychosis with disease duration and of anxiety with increased cognitive impairment [26]. If depressive symptoms occur only during “off” periods, adjustment of antiparkinsonian medication is required [17]. Therefore, to determine when depressive symptoms occur and to adjust and optimize dopaminergic treatment is an important first step in the treatment of depression in PD.

The present analyses showed that for depressive symptoms, 41% of symptomatic individuals (i.e., individuals scoring above the established cutoff of ≥10 on the GDS-30 in screening for depression) were not prescribed any antidepressants. Treatment options for depression that were given the highest priority, i.e., rated as clinically useful in the international PD treatment guidelines, were used only in some cases among the symptomatic individuals of this sample. Dopamine agonist pramipexole, rated as clinically useful in the treatment of depressive symptoms in PD, was prescribed in 17 of 37 (46%) cases where the symptom was present but only in 20 of 63 (32%) cases among the more severely symptomatic individuals (Table 4). However, the indication for prescribing dopamine-agonist pramipexole may not have primarily been the treatment of depressive symptoms. Furthermore, venlafaxine, which has also been rated as clinically useful in the treatment of depressive symptoms, was used only in 1 of 37 (3%) cases where the symptom was present and in 5 of 63 (8%) cases in the more severely symptomatic group. Meanwhile, SSRIs^Prio8, with very low priority in the national guidelines, was prescribed to 21 of the 51 (41%) individuals of the whole cohort who were on antidepressants, while only 6 (12%) were prescribed SNRIs^Prio3 (e.g., venlafaxine), which have a high priority ranking. NaSSAs (e.g., mirtazapine), which have not been given a priority ranking, were the most commonly prescribed class of antidepressants, prescribed to 23 of 51 (45%) individuals (Table 3). However, part of the indication for prescribing mirtazapine may have been concurrent sleep disturbances.

In the total cohort of 107 individuals, 29 (27%) were prescribed antipsychotics. The efficacy of clozapine in the treatment of psychotic symptoms in PD has been confirmed in several studies [27]. Clozapine^Prio3 was prescribed to 9 of 29 (31%) individuals, while quetiapine^Prio7 was prescribed to 20 (69%) (Table 3). As clozapine in the international guidelines has been given the highest rating, clinically useful, while quetiapine was given the rating possibly useful, there may be reason to reconsider which of these medications to prescribe. There may to date be less evidence for the efficacy of quetiapine than clozapine, though a clear advantage with quetiapine over clozapine is easier handling without the need for strict blood monitoring [27]. Only half (9 of 18) of the individuals assessed with more pronounced hallucinations (≥6 on NMSS item, scored 0–12) and 5 of 13 (38%) with more pronounced delusions were prescribed antipsychotics (Table 3). This indicates that there may be a large number of individuals with a substantial symptom burden within this area who are not prescribed any treatment. This may be due to trouble with side effects of the medication such as confusion, sedation, OH, and the risk of agranulocytosis [27], though the present results suggest that it may be important to be aware of these symptoms and attempt to treat them, at least when they become bothersome for the patient. There may be different reasons for the lack of this; one may be not adequate screening of these symptoms in a clinical setting, and another may be underreporting of these symptoms by patients and informal caregivers due to possible embarrassment for such symptoms. Furthermore, concomitant cognitive impairment may contribute to patient loss of insight concerning these symptoms [28–30].

In many cases, it may be sufficient to reduce the dopaminergic therapy and switch to levodopa monotherapy in order to suppress hallucinations and delusions sufficiently. Antidementives are sometimes used as an alternative to antipsychotics when hallucinations are relatively mild. The goal does not have to be to eliminate the hallucinations completely; it is primarily to eliminate hallucinations that disturb the patient.

When it comes to cognitive impairment, another very common NMS in late-stage PD, 60 (58%) of the total sample scored below the general cutoff for cognitive impairment of ≤23 points on the MMSE, and about a quarter of the sample, 27 (26%), scored ≤18 on the MMSE, which may indicate a more substantial cognitive impairment or dementia, i.e., here referred to as symptomatic individuals (Table 1). Acetylcholinesterase inhibitors have been given priority four in the national guidelines, and rivastigmine has been given the rating clinically useful in the international PD treatment guidelines, while donepezil, also priority four in the national guidelines, has been given the rating possibly useful in the international guidelines. In the present cohort, the most common medication for cognitive impairment and dementia was memantine^Prio9, prescribed to 22 of 60 (37%) individuals with symptom present and to 10 of 27 (37%) individuals with more severe symptomatology. This probably reflects the treatment tradition for this group of patients in Sweden presently. Rivastigmine^Prio4 was prescribed to 15 (14%) in the total sample and to only 9 of 27 (33%) of the symptomatic individuals (Table 3). This clearly indicates an undertreatment of these common symptoms in this rather large sample of patients in late-stage PD. As cognitive impairment/dementia are among PD symptoms that affect not only the patients but, to a high degree, also their informal caregivers’ QoL and perceived caregiver burden [31], it is important to recognize these symptoms and to evaluate if symptomatology can be improved with recommended pharmacological therapy. The fact that these therapies often have a relatively weak effect may contribute to some physicians not prescribing them.

OH is yet another common and highly debilitating and troublesome NMS in late-stage PD, which is also a risk factor for falls and fractures in PD [32]. In a previous levodopa test study on the current sample, 21 of 30 (70%) patients exhibited OH, defined as a decrease in blood pressure of ≥20 mm Hg systolic or ≥10 mm Hg diastolic, after three minutes of standing [2, 33]. In this cohort of 107 patients in late-stage PD, 27 (25%) were prescribed antihypotensives. Midodrine^Prio3 was prescribed to 7 of 19 (37%) individuals with a more severe symptomatology of lightheadedness and to 5 of 8 (63%) among those with more severe problems with fainting (Table 3). As motor problems with gait, freezing of gait, and postural instability are very common in late-stage PD [7, 34, 35], the additional risk of falls related to OH should be reduced by adequate pharmacological treatment. Also, fatigue, cognitive difficulties, dizziness, and double vision are common side effects with low blood pressure. However, the main difficulty is to balance the treatment so that the patient does not, at other times, get a too high blood pressure.

Sleep disturbances are yet another category of NMS common in late-stage PD, affecting a large proportion (30–66%) of the sample to some degree (Table 2). Of the total sample, 28 (26%) were prescribed hypnotics. Only one quarter (4 of 16; 25%) of those with more severe symptomatology (≥6 on item 5 of the NMSS, insomnia) were prescribed any hypnotic/sedative/insomnia medication. However, there are several different reasons for sleep disturbances in PD, e.g., problems with “off” time rigidity/bradykinesia, nocturia, and nightmares/hallucinations, which may need other specific treatments.

Patients in late-stage PD are often prescribed several medications and have severe PD symptomatology with a large motor and nonmotor burden. Even though potential side effects on PD features such as OH sometimes may limit treatment options [6], therapeutic gains may be reached also in the vulnerable group of patients in late-stage PD [36]. Thoroughly screening the patients’ symptomatology and creating individualized approaches to therapy, taking possible side effects into consideration, has been recommended [37]. This approach is likely important throughout all stages of PD, not least in the late stage.

There may be a proportion of the sample whose NMS symptomatology responded so well to pharmacological therapy that they did not receive higher scores on the NMSS. Furthermore, with mild symptomatology, it is possible that no pharmacological treatment was given. There may also be individual factors, such as cognition, that influence the way patients respond to questions in the assessment of NMS. However, being a clinician-administered interview-based rating scale, the NMSS scoring is rated in dialogue with the patient and, in some cases, with his/her informal caregiver, assessing both the frequency and severity of each symptom.

An interesting group may be those who do not have any symptoms, though receive treatment. When it comes to depressive symptoms, 51 individuals (48%) of the total sample were prescribed antidepressants, of which 37 scored above the established GDS-cutoff in screening for depression, while the remaining individuals who received antidepressants scored somewhere below the cutoff for depression, which may indicate that there is a treatment effect.

However, in the present study, the individuals with more severe symptomatology who do not have any medication indicate an undertreatment throughout a large range of NMS. There may be different reasons for this, such as medication side effects, interactions with other drugs, comorbidities, and the frailty of the late-stage patient [37]. Another reason could be that the patient due to the severity of the late stage of the disease has difficulty getting to the specialist clinic [6, 10] and is not treated by a physician with a special interest in and knowledge of movement disorders. Many patients have several different NMS, and a specific treatment for each of them could lead to a large number of pharmacological therapies, with the accompanying risk of interactions and side effects. This might limit the possibility of intervening with NMS in some patients. However, since many of the commonly prevalent NMS in late-stage PD are potentially treatable, more attention should be given to the assessment and treatment of NMS in this severely affected population [15].

There is a large variety in treatment strategies for late-stage PD across different countries. Consequently, there is a need to develop guidelines for management in late-stage PD to ascertain that these patients receive the best possible care [6]. This should likely be done both nationally and internationally.

4.1. Strengths, Limitations, and Future Perspectives

Through home visits, we successfully included a large cohort of 107 patients in the late and most severe stage PD, a group often excluded in research, whose situation probably could be improved. In order to assess the prevalence and severity of the various NMS, cutoffs were made to distinguish between individuals with symptoms present, i.e., all individuals who exhibited a symptom and individuals with more severe symptomatology. As there are no recommended cutoffs of the NMSS, we attempted to make a cutoff at ≥ 6 points on each item, on a scale from 0 to 12, in order to distinguish individuals with presumed moderate to severe symptomatology. As for the GDS-30 and the MMSE, generally established cutoffs were used. A hope for the future is improved possibilities to detect NMS, as well as more effective treatment methods with less tendency to side effects and interactions.

Reasons for why overall there is relatively limited use of recommended therapies may include lack of treatment effect, side effects, risk of interactions with other drugs, and patient and informal caregiver refusal of treatment. In addition, there is reason to believe that there is an undertreatment which may be due to the unawareness of treatment options and recommendations.

Future studies on adherence to NMS treatment guidelines in other national contexts would give valuable information on possible differences depending on location and cultural differences.

5. Conclusions

Against a background of the national and international treatment guidelines, individual treatment may be reviewed and optimized throughout all stages of PD, thus improving symptomatology and the overall situation for patients and their families. The present results confirm that NMS are common and pronounced in late-stage PD and the analyses suggest a need for clinicians to further screen for and treat NMS in late-stage PD. Optimizing treatment of NMS according to the national and international treatment guidelines may improve symptomatology and enhance QoL in late-stage PD.

Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

Disclosure

This study was presented as a conference abstract. K. Rosqvist, P. Odin. Compliance with national and international guidelines in the treatment of nonmotor symptoms in late-stage Parkinson’s disease (abstract) Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/compliance-with-national-and-international-guidelines-in-the-treatment-of-non-motor-symptoms-in-late-stage-parkinsons-disease/.

Conflicts of Interest

The authors declare that they have no conflicts of interest. P.O. has received honoraria for lectures and expert advice from AbbVie, BIAL, Britannia, Global Kinetics, Nordic Infucare, PD Neurotechnology, and Zambon.

Acknowledgments

The authors would like to acknowledge the patients and informal caregivers participating in this study and the international CLaSP consortium, coordinated by Professor Anette Schrag. The European CLaSP study was funded through the Joint Programme–Neurodegenerative Disease Research and through the following national funding sources: the Swedish Research Council (CLaSP/JPND HC-559-002); the Swedish Parkinson Foundation; the Skåne Health Care Region; the Faculty of Medicine at Lund University; the Swedish Parkinson Academy; the Greta and Johan Kock Foundation; and the Hardebo Foundation.

References

Socialstyrelsen, “Nationella riktlinjer för vård vid parkinsons sjukdom,” 2016, https://www.socialstyrelsen.se/globalassets/sharepoint-dokument/artikelkatalog/nationella-riktlinjer/2016-12-1-kunskapsunderlag-pd.pdf.
View at: Google Scholar
Swemodis (Swedish Movement Disorder Society), “Riktlinjer för utredning och behandling av parkinsons sjukdom,” 2019, https://www.swemodis.se/wp-content/uploads/2009/10/Swemodis-Riktlinjer-for-utredning-och-behandling-av-Parkinsons-sjukdom-version_8_A4.pdf.
View at: Google Scholar
K. Seppi, K. Ray Chaudhuri, M. Coelho et al., “Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review,” Movement Disorders, vol. 34, no. 2, pp. 180–198, 2019.
View at: Publisher Site | Google Scholar
M. M. Hoehn and M. D. Yahr, “Parkinsonism: onset, progression and mortality,” Neurology, vol. 17, no. 5, pp. 427–442, 1967.
View at: Publisher Site | Google Scholar
M. Coelho and J. J. Ferreira, “Late-stage Parkinson disease,” Nature Reviews Neurology, vol. 8, no. 8, pp. 435–442, 2012.
View at: Publisher Site | Google Scholar
A. Schrag, A. Hommel, S. Lorenzl et al., “The late stage of Parkinson's-results of a large multinational study on motor and non-motor complications,” Parkinsonism & Related Disorders, vol. 75, pp. 91–96, 2020.
View at: Publisher Site | Google Scholar
K. Rosqvist, M. Horne, P. Hagell, S. Iwarsson, M. H. Nilsson, and P. Odin, “Levodopa effect and motor function in late stage Parkinson's disease,” Journal of Parkinson's Disease, vol. 8, no. 1, pp. 59–70, 2018.
View at: Publisher Site | Google Scholar
K. Rosqvist, P. Odin, P. Hagell, S. Iwarsson, M. H. Nilsson, and A. Storch, “Dopaminergic effect on non-motor symptoms in late stage Parkinson's disease,” Journal of Parkinson's Disease, vol. 8, no. 3, pp. 409–420, 2018.
View at: Publisher Site | Google Scholar
K. Rosqvist, P. Odin, S. Lorenzl et al., “Factors associated with health-related quality of life in late-stage Parkinson's disease,” Movement Disorders Clinical Practice, vol. 8, no. 4, pp. 563–570, 2021.
View at: Publisher Site | Google Scholar
N. J. Weerkamp, S. U. Zuidema, G. Tissingh et al., “Motor profile and drug treatment of nursing home residents with Parkinson's disease,” Journal of the American Geriatrics Society, vol. 60, no. 12, pp. 2277–2282, 2012.
View at: Publisher Site | Google Scholar
P. Barone, A. Antonini, C. Colosimo et al., “The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease,” Movement Disorders, vol. 24, no. 11, pp. 1641–1649, 2009.
View at: Publisher Site | Google Scholar
P. Martinez-Martin, C. Rodriguez-Blazquez, M. M. Kurtis, and K. R. Chaudhuri, “The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease,” Movement Disorders, vol. 26, no. 3, pp. 399–406, 2011.
View at: Publisher Site | Google Scholar
D. A. Gallagher, A. J. Lees, and A. Schrag, “What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them?” Movement Disorders, vol. 25, no. 15, pp. 2493–2500, 2010.
View at: Publisher Site | Google Scholar
L. Kadastik-Eerme, M. Rosenthal, T. Paju, M. Muldmaa, and P. Taba, “Health-related quality of life in Parkinson's disease: a cross-sectional study focusing on non-motor symptoms,” Health and Quality of Life Outcomes, vol. 13, no. 1, p. 83, 2015.
View at: Publisher Site | Google Scholar
N. J. Weerkamp, G. Tissingh, P. J. Poels et al., “Nonmotor symptoms in nursing home residents with Parkinson's disease: prevalence and effect on quality of life,” Journal of the American Geriatrics Society, vol. 61, no. 10, pp. 1714–1721, 2013.
View at: Publisher Site | Google Scholar
A. H. V. Schapira, K. R. Chaudhuri, and P. Jenner, “Non-motor features of Parkinson disease,” Nature Reviews Neuroscience, vol. 18, no. 7, pp. 435–450, 2017.
View at: Publisher Site | Google Scholar
D. Aarsland, L. Marsh, and A. Schrag, “Neuropsychiatric symptoms in Parkinson's disease,” Movement Disorders, vol. 24, no. 15, pp. 2175–2186, 2009.
View at: Publisher Site | Google Scholar
K. R. Chaudhuri, D. G. Healy, and A. H. Schapira, “Non-motor symptoms of Parkinson's disease: diagnosis and management,” The Lancet Neurology, vol. 5, no. 3, pp. 235–245, 2006.
View at: Publisher Site | Google Scholar
A. Hommel, M. J. Meinders, S. Lorenzl et al., “The prevalence and determinants of neuropsychiatric symptoms in late-stage parkinsonism,” Movement Disorders Clinical Practice, vol. 7, no. 5, pp. 531–542, 2020.
View at: Publisher Site | Google Scholar
K. R. Chaudhuri, P. Martinez-Martin, R. G. Brown et al., “The metric properties of a novel non-motor symptoms scale for Parkinson's disease: results from an international pilot study,” Movement Disorders, vol. 22, no. 13, pp. 1901–1911, 2007.
View at: Publisher Site | Google Scholar
M. Balzer-Geldsetzer, J. Ferreira, P. Odin et al., “Study protocol: care of Late-Stage Parkinsonism (CLaSP): a longitudinal cohort study,” BMC Neurology, vol. 18, no. 1, p. 185, 2018.
View at: Publisher Site | Google Scholar
R. Schwab and A. England, “Projection technique for evaluating surgery in Parkinson's disease,” in Third Symposium on Parkinson's Disease, F. J. Gillingham and M. C. Donaldson, Eds., pp. 152–157, Livingston, Edinburgh, Scotland, 1969.
View at: Google Scholar
S. Fahn and R. L. Elton, “Members of the UPDRS development committee, unified Parkinson's disease rating scale,” in Recent Developments in Parkinson's Disease, S. Fahn, C. Marsden, D. Calne, and M. Goldstein, Eds., vol. 2, pp. 293–304, MacMillan, Healthcare Information FP, Trenton NJ, USA, 1987.
View at: Google Scholar
M. F. Folstein, S. E. Folstein, and P. R. McHugh, “Mini-mental state,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 189–198, 1975.
View at: Publisher Site | Google Scholar
J. A. Yesavage, T. L. Brink, T. L. Rose et al., “Development and validation of a geriatric depression screening scale: a preliminary report,” Journal of Psychiatric Research, vol. 17, no. 1, pp. 37–49, 1982.
View at: Publisher Site | Google Scholar
D. Weintraub, D. Aarsland, K. R. Chaudhuri et al., “The neuropsychiatry of Parkinson's disease: advances and challenges,” The Lancet Neurology, vol. 21, no. 1, pp. 89–102, 2022.
View at: Publisher Site | Google Scholar
N. Divac, R. Stojanovic, K. Savic Vujovic, B. Medić, A. Damjanović, and M. Prostran, “The efficacy and safety of antipsychotic medications in the treatment of psychosis in patients with Parkinson's disease,” Behavioural Neurology, vol. 2016, Article ID 4938154, 6 pages, 2016.
View at: Publisher Site | Google Scholar
N. Samudra, N. Patel, K. B. Womack, P. Khemani, and S. Chitnis, “Psychosis in Parkinson disease: a review of etiology, phenomenology, and management,” Drugs & Aging, vol. 33, no. 12, pp. 855–863, 2016.
View at: Publisher Site | Google Scholar
J. G. Goldman and E. Sieg, “Cognitive impairment and dementia in Parkinson disease,” Clinics in Geriatric Medicine, vol. 36, no. 2, pp. 365–377, 2020.
View at: Publisher Site | Google Scholar
C. H. Williams-Gray, T. Foltynie, S. J. Lewis, and R. A. Barker, “Cognitive deficits and psychosis in Parkinson's disease: a review of pathophysiology and therapeutic options,” CNS Drugs, vol. 20, no. 6, pp. 477–505, 2006.
View at: Publisher Site | Google Scholar
K. Rosqvist, A. Schrag, and P. Odin, “Caregiver burden and quality of life in late stage Parkinson's disease,” Brain Sciences, vol. 12, no. 1, p. 111, 2022.
View at: Publisher Site | Google Scholar
P. A. LeWitt, S. Kymes, and R. A. Hauser, “Parkinson disease and orthostatic hypotension in the elderly: recognition and management of risk factors for falls,” Aging and disease, vol. 11, no. 3, pp. 679–691, 2020.
View at: Publisher Site | Google Scholar
R. Freeman, W. Wieling, F. B. Axelrod et al., “Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome,” Clinical Autonomic Research, vol. 21, no. 2, pp. 69–72, 2011.
View at: Publisher Site | Google Scholar
B. Debu, C. De Oliveira Godeiro, J. C. Lino, and E. Moro, “Managing gait, balance, and posture in Parkinson's disease,” Current Neurology and Neuroscience Reports, vol. 18, no. 5, p. 23, 2018.
View at: Publisher Site | Google Scholar
M. D. Smith, D. E. Brazier, and E. J. Henderson, “Current perspectives on the assessment and management of gait disorders in Parkinson's disease,” Neuropsychiatric Disease and Treatment, vol. 17, pp. 2965–2985, 2021.
View at: Publisher Site | Google Scholar
A. Hommel, M. J. Meinders, N. J. Weerkamp et al., “Optimizing treatment in undertreated late-stage parkinsonism: a pragmatic randomized trial,” Journal of Parkinson's Disease, vol. 10, no. 3, pp. 1171–1184, 2020.
View at: Publisher Site | Google Scholar
K. Rukavina, L. Batzu, A. Boogers, A. Abundes-Corona, V. Bruno, and K. R. Chaudhuri, “Non-motor complications in late stage Parkinson's disease: recognition, management and unmet needs,” Expert Review of Neurotherapeutics, vol. 21, no. 3, pp. 335–352, 2021.
View at: Publisher Site | Google Scholar

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Copyright © 2023 Kristina Rosqvist and Per Odin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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