Review Article
A Systematic Review and Meta-Analysis of the Efficacy and Safety of Rasagiline or Pramipexole in the Treatment of Early Parkinson’s Disease
Table 2
The main characteristics of the pramipexole studies included in the systematic review.
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AC = anticholinergics, AM = amantadine, COMT-I = Catechol-O-methyl transferase inhibitors, EL = eldepryl, ER = extended release, IR = immediate release, H&Y = Hoehn and Yahr stage, LD = levodopa, MAOB-I = monoamine oxidase B inhibitors, mo = months, NR = not reported, PBO = placebo, PD = Parkinson’s disease, PPX = pramipexole, RA = rasagiline, RCT = randomized controlled trial, RR = ropinirole, SE = selegiline, US = the United States of America, wk = weeks, and yr = years. aIn most studies, doses were titrated at the beginning of the study. Mean values in brackets. bLevodopa with or without carbidopa, levodopa plus carbidopa plus entacapone, or levodopa plus benserazide. cEntacapone or budipine. dThe first 2 yr. are reported in Parkinson Study Group [34] and whole 4 yr. study is reported in Parkinson Study Group [35]. eCarbidopa and levodopa preparation. First value is the amount of carbidopa and the second one is the amount of levodopa. fValues reported of the whole study population (n = 301). gAll subjects that discontinued the study before active treatment at 9 months. This study had a delayed-start design that used placebo until 9 months when patients were switched to placebo. We are reporting the data before the switch to an active treatment. PBO group means in this table the delayed-start pramipexole group. hThe results are reported of patients that completed the study. i94% of study subjects had a H&Y score of ≤2. |