Parkinson's disease (PD) is a complex neurodegenerative process that affects 2% of older people (65 years or older). The global prevalence of PD is projected to double by 2,040, making it the fastest growing neurodegenerative disorder ahead of Alzheimer's disease. There is currently no curative treatment for PD, but there are various drugs that improve the patient's symptoms, both in the initial stages of the disease and in those more advanced. As the disease progresses, the therapeutic window to achieve good symptom control without adverse effects or complications derived from medical treatment narrows.

The prolonged use of these pharmacological therapies will cause motor complications. For instance, motor disorders generated by levodopa, the appearance of "on" and "off" phenomena, mental illness and the appearance of constipation, headache, depression, or sleep disorders. Due to these disorders, non-pharmacological therapies such as physical exercise, speech therapy, occupational therapy, or cognitive stimulation, are equally essential for the most adequate management of the disease. Physical exercise has been shown as the non-pharmacological therapy that has generated the greatest benefits in the patient and in the family environment, not only for preventing the deterioration of the disability. Moreover, physical neurorehabilitation is a valid solution for the symptoms motor, due to its neuroprotective effects and its positive influence on some non-motor symptoms. However, it is only present in less than a third of outpatients, being underused compared to medical treatments. Concepts such as telerehabilitation or neurorehabilitation programs through electronic devices, constitute one of the healthcare services most demanded by patients. These methods are necessary to contrast the effects that these intervention proposals have generated in this group.

The aim of this Special Issue is to bring together original research and review articles discussing therapeutic physical interventions in the population diagnosed with Parkinson's. We welcome submissions including exergaming programs, telerehabilitation, virtual reality (immersive and non-immersive), augmented reality, programs of neurorehabilitation through electronic devices, as well as other innovative proposals for physical intervention such as high intensity calisthenics, assisted vs resisted physical exercise, etc.

Potential topics include but are not limited to the following:

• Virtual reality in Parkinson's disease
• Telerehabilitation for Parkinson's disease
• E-health for patients with Parkinson's disease
• Exergaming for patients with Parkinson's disease
• Augmented reality for patients with Parkinson's disease
• Neurorehabilitation for patients with Parkinson's disease
• Physical activity in patients with Parkinson's disease
• Resisted and assisted training in Parkinson's disease
• Aquatic therapy for patients with Parkinson's disease
• Exercise mobile applications for patients with Parkinson's disease