A Novel Mechanism for Cross-Adaptation between Heat and Altitude Acclimation: The Role of Heat Shock Protein 90

<table>In normoxia, HIF1α is hydroxylated by PHD. Hydroxylated HIF1α undergoes protein degradation via vHL proteasome pathway. In hypoxia, PHD does not hydroxylate HIF1α. Stabilized HIF1α is translocated across nucleus membrane dimerizing with HIF1β. Dimerization of HIF1α/β increases HIF1 transcription factor which binds to HRE of DNA. This increases VEGF and EPO production. HIF1α: hypoxic-inducible factor 1α/β; PHD: prolyl-hydroxylase; vHL: von Hippel-Lindau; VEGF: vascular endothelial growth factor; HRE: hypoxic response element.</table>

Physiology Journal

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Figure 1: A Novel Mechanism for Cross-Adaptation between Heat and Altitude Acclimation: The Role of Heat Shock Protein 90 