c-SRC tyrosine kinase induced pro-MMP-2 activation in the presence of MMP-14; MMP-2 found in high concentrations in SCLC.
[28]
Cell proliferation and inhibition of angiogenesis
Various types of lung cancers
Inhibition of VEGF-A and FGF-2 in vitro and in vivo. TIMP2 can bind α3β1 integrin heterodimer and stimulate SHP1-mediated dephosphorylation of FGFR1 or EGFR.
TIMP2 colocalizes with Ki67+fibroblasts in IPF lungs; TIMP2 observed along with MMP1, 2, and 9 in regenerated epithelial cells covering intra-alveolar fibrosis.
TNFα/IL1β regulate TIMP2 expression in cardiac cells; inhibition of TIMP2 in microglial cells increase cytokine production. TIMP2 suppresses microglial activation through regulation of Nrf2 and cAMP-response element binding protein transcription factors.