PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5′-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells

Figure 1

Effect of fenofibrate and related compounds on levels of eNOS (a, b) and NO (c) in control group, LPS group, fenofibrate pretreated group, PPARα antagonist, and agonist group. eNOS and NO were measured by ELISA kits according to the manufacturer’s protocols. Values are expressed as means ± SD. (a) *𝑃<0.05 versus control group. (b, c) *𝑃<0.05; ^#𝑃<0.05 versus LPS group.

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