Research Article
Peptide Helix-Y12 as Potential Effector for Peroxisome Proliferator-Activated Receptors
Figure 1
Molecular structure of protein targets: (a) co-crystallized in complex with a corresponding active molecule in the LBD (holo state) PPARα-ET1 (PDBID: 3ET1, in red), PPARβ/δ-D32 (PDBID: 3GZ9, in green), and PPARγ-CTI (PDBID: 4Y29, in blue). (b) Top 5 cavities, ranked by size, LBD in red 458 Å3, green 63 Å3, blue 52 Å3, purple 42 Å3, and orange 1 Å3 (volumes calculated with the CASTp 3.0 [76] on 3GZ9). Helix pairs H4–H5 and H10–H11 are continuous secondary structures.
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