Research Article
Immunohistochemical Investigation of HER/AKT/mTOR Pathway and Cellular Adhesion Molecules in Urothelial Carcinomas
Table 2
Immunohistochemical distribution of the examined markers.
| | | % |
| HER2 | | | 0 | 8 | 19.5 | 1+ | 14 | 34.1 | 2+ | 11 | 26.8 | 3+ | 8 | 19.6 |
| EGFR | | | Negative | 27 | 65.9 | Positive | 14 | 34.1 |
| pAKT nuclear | | | Negative | 17 | 41.5 | Positive | 24 | 58.5 |
| pAKT cytoplasmic | | | Negative | 29 | 70.7 | Positive | 12 | 29.3 |
| PTEN cytoplasmic | | | Negative | 19 | 47.5 | Positive | 21 | 52.5 | Missing data | 1 | — |
| PTEN nuclear | | | Negative | 31 | 77.5 | Positive | 9 | 22.5 | Missing data | 1 | — |
| PTEN nuclear/cytoplasmic | | | Negative | 10 | 25 | Positive | 30 | 75 | Missing data | 1 | — |
| pmTOR | | | Negative | 19 | 46.3 | Positive | 22 | 53.7 |
| MIB1 | | | ≤20 | 23 | 56.1 | >20 | 18 | 43.9 |
| e-cadherin | | | Negative | 16 | 45.7 | Positive | 19 | 54.3 | Missing data | 6 | — |
| p-cadherin | | | Negative | 20 | 58.8 | Positive | 14 | 41.2 | Missing data | 7 | — |
| b-catenin | | | Negative | 10 | 28.6 | Positive | 25 | 71.4 | Missing data | 6 | — |
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