Molecular mechanisms of recent advances in our understanding of gastrointestinal neoplasia have led to the discovery of important molecular alterations that are characteristic of gastrointestinal malignancies, some of which may represent therapeutic targets. Although some changes, such as TP53 tumor suppressor gene mutations, are frequently observed in a variety of different types of cancer, dysplastic precursors, and preneoplastic conditions, an increasing number of different cancers have been shown to harbor relatively specific oncogenic mutations that may be exploited, or manipulated, by novel interventions. As a result, pathologists are increasingly asked to evaluate patient materials for the presence of molecular alterations that may impact patient care.

We invite investigators to contribute original research articles as well as review articles describing the pathologic and molecular features of gastrointestinal malignancies. These manuscripts should stimulate continued efforts to understand the relationships between morphology and molecular alterations, and discuss their roles in emerging treatment strategies for the management of cancers of the gastrointestinal tract. We are particularly interested in articles describing organ-specific molecular testing among gastrointestinal malignancies and the implications of molecular changes on patient treatment.

Potential topics include, but are not limited to:

• Her-2/neu amplification in adenocarcinomas of the esophagus and stomach
• The role of EGFR signaling in gastrointestinal carcinogenesis
• Implications of KRAS mutations for management of patients with colorectal carcinoma
• Microsatellite instability and gastrointestinal neoplasia
• DNA methylation and epigenetics
• Gastrointestinal stromal tumors: Molecular mechanisms and targeted therapies
• Molecular classification of hepatocellular neoplasms
• Molecular features of pancreatic ductal neoplasia
• Inflammatory mediators in the evolution of inflammatory bowel disease: A basis for targeted therapy

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/pri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable: