Can Prenatal Diagnosis of Total Anomalous Pulmonary Venous Return (TAPVR) Using Routine Fetal Ultrasound be Improved? A Case-Control Study

Table 2

Sensitivity and specificity (with 95% confidence intervals) of the proposed diagnostic algorithms of TAPVR.

Diagnostic algorithm	Specificity (95% CI)	Sensitivity (95% CI)
Algorithm ^#1—any 3+ markers	97.6% (91.5–99.7%)	10% (1.2–31.7%)
Algorithm ^#2—any 4+ markers	98.8% (93.4–99.9%)	10% (1.2–31.7%)
Algorithm ^#3—absence PVs & abn CR	90.5% (82.1–95.8%)	61.9% (38.3–61.9%)
Algorithm ^#4—absence PVs & 3+ markers	94.1% (86.7–98.1%)	23.8% (8.2–47.2%)
Algorithm ^#5—absence PVs & 4+ markers	95% (8.7%–98.1%)	18% (8.7–63%)

Legend. “absence of PVs & abn CR” (algorithm starts with stratification by nonvisualization of pulmonary vein entry into LA, followed by an abnormal Coumadin ridge); “absence of PVs & 3+ markers” (algorithm starts with stratification by nonvisualization of pulmonary vein entry into LA, followed by presence of 3 or more markers of TAPVR); “absence of PVs & 4+ markers” (algorithm starts with stratification by nonvisualization of pulmonary vein entry into LA, followed by presence of 4 or more markers of TAPVR).