Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling

<div>Jagged 1 in FDMSC exosomes can promote the wound-healing capacity of ADFs. (a) The expression of Jagged 1 in FDMSC exosomes was knocked down by siRNA. (b) Western blot analysis of Notch1 and Hes 1 protein levels in ADFs treated with SFM, FDMSC exosomes, Jagged 1 peptide, or Jagged 1 siRNA exosomes. GAPDH served as a loading control. Notch1 and Hes 1 were upregulated in the exosome and Jagged 1 peptide treatment groups, while in Jagged 1 siRNA exosome treatment group, the activating effect of FDMSC exosomes on the Notch signal was abolished after Jagged 1 knockdown. (c) The proliferation of ADFs. (d, e) The migration of ADFs. (d) Cell migration is expressed as a percentage of control. 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Stem Cells International

fig6

Figure 6

Figure 6: Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling 