Factors Predicting Ventilator Dependence in Patients with Ventilator-Associated Pneumonia

Table 2

Baseline VAP patients characteristics^a.

Characteristics	Ventilator independence	Ventilator dependence	𝑃 value
	𝑁=36	𝑁=54
Age	66.08 ± 15.69^d	66.46 ± 14.66^d	0.91
Sex			0.55
Male, number (%)	21 (58)^d	28 (52)^d
Female, number (%)	15 (42)^d	26 (48)^d
SOFA^b score	7.61 ± 2.42^d	10.41 ± 2.02^d	<0.001
Apache II score	23.25 ± 4.72^d	25.76 ± 3.75^d	0.006
Reason of respiratory failure			<0.001
Pneumonia	5 (14)^d	18 (33)^d
COPD^b with AE^b	6 (17)^d	19 (35)^d
Cardiogenic	6 (17)^d	12 (22)^d
GI^b bleeding	2 (6)^d	0 (0)^d
Terminal malignancy	4 (11)^d	2 (4)^d
Other infections	13 (36)^d	3 (6)^d
Charlson comorbidity Index^c	2.36 ± 1.29^d	2.39 ± 1.79^d	0.91
ARDS^b status	5	30	<0.001
Comorbidities
Chronic lung disease	5 (14)^d	26 (48)^d	0.001
CHF^b	6 (17)^d	30 (56)^d	<0.001
Liver cirrhosis	2 (6)^d	1 (2)^d	0.34
End-stage renal disease	5 (14)^d	7 (13)^d	0.93
Neoplastic disease	3 (8)^d	8 (15)^d	0.36
Diabete mellitus	13 (36)^d	17 (31)^d	0.65
Old CVA^b	16 (44)^d	23 (43)^d	0.86
Septic shock	8 (22)^d	10 (19)^d	0.67
Tracheostomy before VAP^b	3 (8)^d	19 (35)^d	0.004
Tracheostomy after VAP^b	10 (28)^d	9 (17)^d	0.29
Overall tracheostomy	13 (36)^d	28 (52)^d	0.20

^a Continuous variables were analyzed by Student’s 𝑡-test or Mann-Whitney 𝑈 test, and categorical data by chi-square test.
^b AE: acute exacerbation, APACHE: Acute Physiological Assessment and Chronic Health Evaluation, ARDS: acute respiratory distress syndrome, CHF: congestive heart failure, COPD: chronic obstructive pulmonary disease, CVA: cerebrovascular accident, GI: gastrointestinal, SOFA: Sequential Organ Failure Assessment, VAP: ventilator associated pneumonia.
^c Disease was defined as in the Charlson comorbidity index.
^d Variables are expressed as mean (standard deviation) and categorical data are expressed as number (percentage).