In Silico Evolution of Gene Cooption in Pattern-Forming Gene Networks
Figure 3
Biological data used to fit ODE model by GA. Integrated gene expression profiles for mid nuclear cleavage cycle 14 A. Vertical axis, relative protein concentration (proportional to intensity); horizontal axis, relative position along the anteroposterior (AP) embryo axis (0% is the anterior pole). Data from the FlyEx database [14]. (a) Protein profiles for four trunk gap genes (giant; gt, hunchback, hb; Kruppel, Kr; & knirps, kni). The red rectangle marks the part of the AP axis modeled in this publication. Models are fit to the Kr and kni data. (b) Profiles of two proteins which are external inputs in our simulations (the primary morphogen Bicoid, Bcd, and the transcription factor Caudal, Cad).
