Morphological Aspects and Immunophenotypic Profiles of Mammary Carcinomas in Benign-Mixed Tumors of Female Dogs

Figure 1

Immunophenotypic profiles of mammary carcinomas in benign-mixed tumors of female dogs’ mammary gland: Canis familiaris. (a)–(d) ER staining; (e)–(h) PR staining; (i)–(l) HER2 staining; (m)–(p) EGFR staining; (q)–(t) CK5 staining. Each column represents a distinct molecular subtype. From left to right: luminal A (case 13—RE: positive, RP: positive, HER2: negative, EGFR: negative, and CK5: positive). Luminal B (case 21—RE: positive, RP: positive, HER2: positive, EGFR: negative, and CK5: positive), HER2 (case 20—RE: negative, RP: negative, HER2: positive, EGFR: negative, and CK5: negative), and basal-like (case 17—RE: negative, RP: negative, HER2: negative, EGFR: positive, and CK5: positive). Advance HRP visualization method streptavidin-biotin complex method. Mayer’s hematoxylin counterstain Bar: 25 𝜇m.

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