The Roles of miR-26, miR-29, and miR-203 in the Silencing of the Epigenetic Machinery during Melanocyte Transformation

Figure 4

miR-26 expression during melanocyte transformation and 5-aza-CdR treatment. miR-26a (a) and miR-26b (b) expression was examined in the three cell lines using qRT-PCR. The cells were treated with 10 μM 5-aza-CdR for 48 hours, and the expression of miR-26a (c) and miR-26b (d) was subsequently evaluated. U6 was used for normalization. Ma: nontumorigenic melan-a melanocyte lineage; 4C3−: nonmetastatic melanoma cell line; and 4C3+: metastatic melanoma cell line. ; ; .

(a)

(b)

(c)

(d)