Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease

Table 1

Demographic characteristics of examined cohort.

	Examined (40)		Control (36)		Difference and significance
Age (yrs., mean ± SD)	47.88 ± 6.07		47.07 ± 6.68		NS
Sex (male/female)	22/18		16/14		NS
Body mass index (BMI, kg/m^2, mean ± SD)	32.04 ± 6.67		22.18 ± 4.43
Diabetes type 2 (yes/no)	12/28		9/27		NS
Hypertension (yes/no)	32/8		16/20		Spearman correlation NAFLD + and hypertension,
HDL/LDL ratio (mean ± SE)	4.49 ± 0.23		2.94 ± 0.18
Status according to BMI:
Normal	5		21
Overweight	15		11
Obese	20		4
Metabolic syndrome (yes/no)	34/6		8/28		Chi square,
MoCA score (mean ± SD)	24.07 ± 3.18		27.17 ± 2.35
Total brain volume (cm^3, mean ± SD)	1388 ± 127.98		1417 ± 191.83		NS
Gray matter volume (gmw in cm^3 mean ± SD)	405 ± 37.42		414 ± 56.09		NS
White matter volume (wmw, in cm^3 mean ± SD)	338 ± 31.21		344 ± 46.83		NS
Lateral ventricle volume, right/left (lvlr, lvll, in cm^3 mean ± SD)	5.97 ± 0.61	6.07 ± 0.62	5.64 ± 0.37	5.63 ± 0.37
AST (U/l, mean ± SE)	39.97 ± 2.61		24.03 ±3.26
ALT (U/l mean ± SE)	39.11 ± 2.86		36.71 ± 3.5		NS
AST/ALT ratio (mean ± SE)	1.13 ± 0.11		0.7 ± 0.06
C-reactive protein (mg/l, mean ± SE)	3.96 ± 0.45		3.52 ± 0.51		NS
Fasting glycaemia (mmol/l, l mean ± SE)	5.8 ± 0.19		3.71 ± 0.25
Triglycerides (mmol/l, l mean ± SE)	2.87 ± 0.18		1.71 ± 0.17

NS, not significant; SE, standard error. Lateral ventricle volumes.