Case Report

Inv(3) Acute Myeloid Leukemia in a Young Adult and Review of the Literature

Table 2

Active immunotherapy clinical trials for pediatric and young adult AML.

Study titleNCT numberTherapeutic interventionCountry

First-in-human Study of SAR443579 Infusion in Male and Female Participants of at Least 12 Years of Age with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL) or High Risk- myelodysplasia (HR-MDS)NCT05086315Drug: SAR443579USA, Australia, France, Netherlands
Phase I/II Study of Enhanced CD33 CAR T Cells in Subjects with Relapsed or Refractory Acute Myeloid LeukemiaNCT04835519Biological: chimeric antigen receptor T cellChina
CLL-1/CD33 Targeted LCAR- AMDR Cells in Patients with Relapsed or Refractory Acute Myeloid LeukemiaNCT05654779Biological: LCAR-AMDR Cells ProductChina
Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults with Relapsed/Refractory Acute Myeloid LeukemiaNCT03971799Biological: CD33CARTUSA
Anti-FLT3 CAR T-cell Therapy in FLT3 Positive Relapsed/ Refractory Acute Myeloid LeukemiaNCT05023707Biological: anti-FLT3 CAR-TChina
Anti-CLL1 CAR T-cell Therapy in CLL1 Positive Relapsed/ Refractory Acute Myeloid Leukemia (AML)NCT04884984Biological: anti-CLL1 CARTChina
CD123-Targeted CAR-T Cell Therapy for Relapsed/Refractory Acute Myeloid LeukemiaNCT04265963Biological: CD123 CAR-T cellsChina
CD38-targeted Chimeric Antigen Receptor T Cell (CART) in Relapsed or Refractory Acute Myeloid LeukemiaNCT04351022Biological: CART-38China
Safety and Efficacy Study of CI-135 CAR-T Cells in Subjects with Relapsed or Refractory Acute Myeloid LeukemiaNCT05266950Biological: CI-135 CAR-T cellsChina
Safety and Efficacy of CD123- Targeted CAR-T Therapy for Relapsed/Refractory Acute Myeloid LeukemiaNCT04272125Biological: CD123 CAR-T cellsChina
PLAT-08: A Study Of SC- DARIC33 CAR T Cells in Pediatric and Young Adults with Relapsed or Refractory CD33+ AMLNCT05105152Biological: SC-DARIC33USA
CART-19 T Cell in CD19 Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)NCT03896854Biological: CART-19China
NKG2D CAR-NK & relapsed/refractory AMLNCT05734898Biological: NKG2D CAR-NKChina
Safety and Preliminary Efficacy of JK500 Cell Injection in Relapsed/Refractory Pediatric Acute Myeloid LeukemiaNCT05519384Drug: JK500 cell injectionChina
Optimized Dual CD33/CLL1 CAR T Cells in Subjects with Refractory or Relapsed Acute Myeloid LeukemiaNCT05248685Biological: Dual CD33/CLL1 CAR TChina
Multi-institutional Prospective Research of Expanded Multi- antigen Specifically Oriented Lymphocytes for the Treatment of Very High-Risk Hematopoietic MalignanciesNCT02203903Biological: tumor-associated antigen lymphocytesUSA

Clinical trials found on http://www.clinicaltrials.gov as of 1 June 2023.