Research Article
Hydroxychloroquine: Pharmacokinetics and Toxicity
Table 2
HCQ serum concentrations two days after treatment onset according to age, sex, comedications, and comorbidities.
| | HCQ serum concentration (μg/mL) two days after treatment onset | n | Mean (SD) | (Kruskal–Wallis test) |
| Age (years) | | | | >64 | 70 | 0.17 (0.18) | 0.0001 | 55–64 | 68 | 0.19 (0.11) | | 45–54 | 53 | 0.23 (0.11) | | 18–44 | 106 | 0.20 (0.12) | | Sex | | | | Women | 159 | 0.22 (0.15) | 0.0009 | Men | 138 | 0.17 (0.10) | | Body mass index | | | | <30 | 20 | 0.17 (0.08) | 0.0637 | >30 | 19 | 0.12 (0.08) | | Comedications (≥5 drugs) | | | | No | 95 | 0.21 (0.12) | 0.129 | Yes | 183 | 0.19 (0.14) | | Comedications (≥8 drugs) | | | | No | 274 | 0.20 (0.13) | 0.539 | Yes | 4 | 0.24 (0.17) | | Number of comorbidities | | | | 0 | 169 | 0.21 (0.11) | 0.0002 | 1 | 71 | 0.20 (0.17) | | 2 | 40 | 0.15 (0.13) | |
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