Research Article

Hydroxychloroquine: Pharmacokinetics and Toxicity

Table 2

HCQ serum concentrations two days after treatment onset according to age, sex, comedications, and comorbidities.

HCQ serum concentration (μg/mL) two days after treatment onset
nMean (SD) (Kruskal–Wallis test)

Age (years)
 >64700.17 (0.18)0.0001
 55–64680.19 (0.11)
 45–54530.23 (0.11)
 18–441060.20 (0.12)
Sex
 Women1590.22 (0.15)0.0009
 Men1380.17 (0.10)
Body mass index
 <30200.17 (0.08)0.0637
 >30190.12 (0.08)
Comedications (≥5 drugs)
 No950.21 (0.12)0.129
 Yes1830.19 (0.14)
Comedications (≥8 drugs)
 No2740.20 (0.13)0.539
 Yes40.24 (0.17)
Number of comorbidities
 01690.21 (0.11)0.0002
 1710.20 (0.17)
 2400.15 (0.13)