Hydroxychloroquine: Pharmacokinetics and Toxicity

Table 6

HCQ concentration in serum according to clinical outcome.

Days		2	4	6	8	10	12	14
Good outcome	n	255	96	33	17	118	35	109
	(HCQ)	0.19 ± 0.12	0.38 ± 0.23	0.51 ± 0.29	0.43 ± 0.19	0.67 ± 0.32	0.518 ± 0.38	0.42 ± 0.33
Poor outcome	n	42	28	27	22	18	5	4
	(HCQ)	0.18 ± 0.21	0.32 ± 0.18	0.42 ± 0.29	0.64 ± 0.31	0.86 ± 0.52	0.59 ± 0.25	0.34 ± 0.22

“Poor outcome” means hospitalisation ≥10 days, ICU admission, or death. “Good outcome” means none of the severity markers of these three outcomes. n: number of tested patients at each time point. (HCQ): HCQ concentrations over time (μg/mL, mean ± SD).