Risk of Dementia in Patients with Depression or Parkinson’s Disease: A Retrospective Cohort Study

Table 4

Incident rate and hazard ratio for dementia with PD in depression subgroups with cutoff age at 65.

Group	Without PD	With PD	Crude HR (95% CI)		Adjusted HR^b (95% CI)
	Incident rate^a	Incident rate^a
No depression
<65	0.7	9.1	12.56 (5.84–27.00)	<0.001	10.08 (4.67–21.76)	<0.001
≧65	14.8	44.8	3.10 (2.48–3.88)	<0.001	2.99 (2.39–3.74)	<0.001
Depression
<65	1.1	4.6	4.29 (0.53–34.88)	0.173	7.06 (0.83–60.24)	0.074
≧65	22.8	32.6	1.43 (0.82–2.47)	0.206	1.55 (0.89–2.71)	0.120

Note. PD = Parkinson’s disease, HR = hazard ratio, CI = confidence interval, n = case number, % = percentage, and  =  value. ^aPer 1000 person-years. ^bAdjusted HR: adjusted for age, gender, hypertension, diabetes mellitus, hyperlipidemia, and ischemic heart disease.