Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study

Table 2

Comparison of demographic and clinical characteristics between cognitive decline and cognitive maintained groups.

Group	PD-MCI cognitive decline group N = 10	PD-MCI cognitive maintained group N = 25	value	AD-MCI N = 3	AD-MCI N = 36	value
No (%)	10 (28.6)	25 (71.4)	—	3 (7.7)	36 (92.3)	—
Median age of visit	72	66	0.400	71	70	0.833
Male (%)	2 (20)	15 (60)	0.035	1 (33.3)	22 (61.1)	0.354
Education (year)	8.40	8.64	0.843	7.00	7.61	0.901
BMI	23.08	24.24	0.466	21.78	24.22	0.228
MMSE	26.50	25.52	0.339	25.33	24.89	0.709
CDR-SB	2.25	1.32	0.023	2.67	1.76	0.295
CVLT-SF immediate recall	5.00	5.67	0.148	4.00	5.58	0.140
CVLT-SF delayed recall	4.00	4.63	0.304	2.33	4.69	0.100
CVLT-SF recognition	5.20	5.71	0.445	3.00	5.31	0.112
TCF copy	30.06	31.75	0.254	28.00	30.17	0.100
TCF recall	11.22	15.11	0.219	5.00	14.49	0.126
JLO	12.67	14.08	0.462	13.33	13.37	0.799
Forwards digit recall	6.10	7.42	0.034	7.33	7.42	0.746
Backward digit recall	3.50	4.00	0.515	4.67	4.20	0.682
Trail making test A	26.89	31.28	0.953	21.67	23.48	0.759
Trail making test B	75.89	69.80	0.648	69.67	58.50	0.773
Verbal fluency animal	11.10	12.71	0.381	15.00	11.92	0.112
Boston naming Test	21.30	24.46	0.038	21.33	21.75	0.785
CTP recall	12.56	13.36	0.781	12.33	14.22	0.709
CTP recognition	16.22	16.27	0.915	16.33	17.72	0.599
GDS-15 > 5 (%)	4 (40.0)	4 (17.4)	0.170	3 (33.3)	5 (13.9)	0.376
PSQI > 5 (%)	8 (88.9)	8 (36.4)	0.009	3 (100)	16 (44.4)	0.068
Barthel index	91.00	94.79	0.539	100.00	99.31	0.823
IADL	16.90	21.13	0.042	22.33	23.06	0.295
Tinetti balance	13.00	14.62	0.348	15.67	15.56	0.823
Tinetti gait	9.90	11.52	0.105	12.00	11.83	0.823
Walking speed (m/s)	0.744	0.855	0.304	0.817	0.883	0.501
Cadence (steps/min)	101.77	97.13	0.642	90.44	98.17	0.294
Stride length (cm)	56.78	69.92	0.101	68.56	67.64	0.839
TUG total (s)	28.69	16.34	0.050	16.78	15.63	1.00
TUG sit-to-stand (s)	2.17	1.84	0.086	1.53	1.69	0.599
TUG mid-turnings (s)	4.06	2.65	0.081	2.34	2.60	0.941
TUG end-turnings (s)	4.20	2.48	0.051	1.90	2.14	0.785
TUG stand-to-sit (s)	2.97	2.37	0.079	2.17	2.60	0.374

values calculated using fisher’s exact test and Mann–Whitney U test, as appropriate. Statistically significant result, values <0.05.