Review Article
Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Table 1
The function of MSCs in mediating immune cells both in innate and adaptive immune systems.
| Immune cell type | MSC functions |
| Innate immune systems | ā | DCs | Inhibiting DC migration, activation, differentiation, maturation, and endocytosis | NK cell | Inhibiting NK cell migration, proliferation, differentiation, maturation, and activation | Macrophage | Activating M2 macrophage polarization in general; activating M1 macrophage polarization in specific microenvironment |
| Adaptive immune systems | ā | T cell | Inhibiting T-cell survival proliferation, differentiation, maturation, and activation, while accelerating T-cell recruitment | B cell | Inhibiting B-cell proliferation, differentiation, maturation, chemotaxis, and activation |
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