Review Article

The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence

Table 1

Summary of the differences between PRP and PRF [45, 53].

PDBsPlatelet-rich plasma (PRP)Platelet-rich fibrin (PRF)

Type of additive in the blood sampleAnticoagulant (bovine thrombin/calcium chloride)None
Fibrin polymerization rateRapid (dependent upon the amount of anticoagulant)Gradual (natural polymerization in the glass/blood contact area)
Quality of the fibrin networkRigid network (condensed tetra-molecular/bilateral junctions due to high anticoagulant content)Flexible network (trimolecular or equilateral junctions)
Effect of fibrin network on cell migration and cytokine releaseUnfavorable (due to network rigidity)Favorable (due to network flexibility)
Modulus of elasticity of the fibrin networkHigh (due to network rigidity)Low (due to network flexibility)